Fig. 9: CD8+ T cell internalisation into BEC is a consistent event in PBC patients with ongoing disease.
From: Expression of E-cadherin by CD8+ T cells promotes their invasion into biliary epithelial cells
a Representative fluorescence image of liver core biopsy, taken from a primary biliary cholangitis (PBC) patient with active disease, stained for CD8 (magenta), CD103 (green) and CK19 (orange) by immunohistochemistry (IHC). Right panel shows magnified image of left panel inset (yellow box) and identifies a cluster of bile ducts. b Multichannel representation of orthographical views showing bile duct outlined in part (a) (red box) showing internalised CD8+ CD103+ T cell (white arrow). c Magnified single Z-plane image of inset shown in (b) (green box). d Percentage of biopsy samples showing evidence of internalised CD8+ and CD103+ CD8+ T cells within BEC. n = 9 biologically independent patient samples.
