Fig. 3: Predicted risk of MS by Sex and model calibration plots for 5-, 10-, and 20-year horizons. | Nature Communications

Fig. 3: Predicted risk of MS by Sex and model calibration plots for 5-, 10-, and 20-year horizons.

From: Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis

Fig. 3

Panel (a) shows boxen plots of predicted partial hazard based on participants’ MS-GRS, sex and age at ON diagnosis for undifferentiated ON that did not develop MS (ON only, red) and those who did (MS-ON, blue) by the end of cumulative follow-up. Grey centerline shows the median, with the darkest shade around showing second and third quartiles. Each successive level outward contains half of the remaining data and is shaded in lighter colour. Outliers are shown as diamonds. Panels (b–d) illustrate calibration plots of the Cox model at three points in time (5, 10, and 20 years, respectively). The smoothed calibration curve is shown in red, and ideal calibration as a black dotted line. X-axis is the predicted probability of developing MS up to 5, 10, and 20 years post ON diagnosis for (b–d), respectively.

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