Fig. 1: Structure of AE2 in complex with PIP2.
From: Structural and functional insights into the lipid regulation of human anion exchanger 2
a, b Cryo-EM density map of AE2IF/PIP2, viewed from the side (a) and the cytoplasmic side (b). The approximate position of the lipid bilayer is indicated by gray bars. The two protomers, PIP2 and lipid-like densities are colored in green, blue, yellow and gray, respectively. c Structural model of AE2 shown in cylinder representation. The core domain, gate domain, and intracellular helices of one transmembrane domain (TMD) are colored in green, blue and pink, respectively. The other protomer is colored in gray. d Cartoon illustrating the topology of AE2. The N-terminal cytoplasmic domain (NTD, amino acids 320-431 and 503–586) is colored in orange and other structural features are colored as in panel c.
