Fig. 2: PIP2 binding site in AE2.
From: Structural and functional insights into the lipid regulation of human anion exchanger 2
a Surface representation of AE2 colored according to its electrostatic surface potentials. PIP2 is shown as sticks and colored in yellow. TM7 and HL are indicated in Fig. 1d. b, c Close-up view of the PIP2 binding site. Densities of PIP2 and amino acids R932, K1147 and H1148 are shown in mesh. PIP2 and the two protomers of AE2 are colored in yellow, blue and green, respectively. PIP2 and the amino acids that interact with PIP2 are shown as sticks.
