Table 2 The association (relative risks [RR], 95% confidence intervals (95%CIs)) between reported symptoms and reinfections

From: Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population

(a)

No symptom

With symptom

Model without Ct

 

reference

RR

95%CI

p-value

Infection (2 vs 1)

0.64

0.63–0.66

<2e–16

Infection (3 vs 1)

0.60

0.55–0.65

<2e–16

Model adjusted for Ct

 

reference

RR

95%CI

p-value

Infection (2 vs 1)

0.59

0.56–0.60

<2e–16

Infection (3 vs 1)

0.53

0.48–0.59

<2e–16

(b)

No symptom

Classic symptoms

Other symptoms

Model without Ct

 

reference

RR

95%CI

p-value

RR

95%CI

p-value

Infection (2 vs 1)

0.60

0.59–0.62

<2e–16

0.98

0.95–1.02

0.3

Infection (3 vs 1)

0.54

0.50–0.59

<2e–16

1.20

1.08–1.34

0.001

Model adjusted for Ct

 

reference

RR

95%CI

p-value

RR

95%CI

p-value

Infection (2 vs 1)

0.54

0.52–0.56

<2e–16

0.91

0.87–0.96

0.0002

Infection (3 vs 1)

0.50

0.45–0.55

<2e–16

1.12

0.98–1.30

0.08

  1. (a) Multivariable logistic regression model examining any reported symptoms vs no reported symptoms. (b) Multivariable multinomial regression model examining reported classic symptoms (any of cough, fever, loss of taste/smell) and other symptoms (myalgia, fatigue/weakness, sore throat, shortness of breath, headache, diarrhoea, nausea, abdominal pain) among participants with self-reported symptom information from the study (i.e. excluding those with only symptom presence/absence from the national testing programme). Models were adjusted for age, sex, ethnicity, reporting working in healthcare, reporting having a long-term health condition, deprivation percentile, infection variant, time from most recent vaccination. Separate models were built further adjusted for Ct values in the current infection. Two-sided z-test was used to test the significance of model coefficients. The 95% CIs are calculated as estimates ± 1.96 × standard error of the estimates.
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