Table 2 Proteins dysregulated in critical disease and modulated by imatinib
Protein | GeneID | Change in critical disease | Imatinib effect |
|---|---|---|---|
Angiopoietin-related protein 3 | ANGPTL3 | Increase | Decrease |
Collagen alpha-1(XXVIII) chain | COL28A1 | Increase | Decrease |
Collagen alpha-1(I) chain:C-term propeptide | COL1A1 | Increase | Decrease |
Collagen alpha-3(VI) chain:Bovine pancreatic trypsin inhibitor/Kunitz inhibitor domain, isoform 1 | COL6A3 | Increase | Decrease |
Serine protease 27 | PRSS27 | Decrease | Increase |
Serpin B13 | SERPINB13 | Decrease | Increase |
Collagen Type III | COL3A1 | Increase | Decrease |
Calcipressin-3 | RCAN3 | Increase | Decrease |
Collagen alpha-1(V) chain | COL5A1 | Increase | Decrease |
Interleukin-6 | IL6 | Increase | Decrease |
Luteinizing hormone | CGA|LHB | Decrease | Increase |
Tumour necrosis factor ligand superfamily member 15 | TNFSF15 | Increase | Decrease |
Biglycan | BGN | Increase | Decrease |
Thrombospondin-2 | THBS2 | Increase | Decrease |
Urokinase-type plasminogen activator | PLAU | Increase | Decrease |
Repulsive guidance molecule A | RGMA | Decrease | Increase |
Apolipoprotein D | APOD | Decrease | Increase |
Olfactomedin-like protein 3 | OLFML3 | Increase | Decrease |
Platelet-derived growth factor D | PDGFD | Decrease | Increase |
