Fig. 8: cGAS/STING-driven neuroinflammation associated with aging is modulated by mitophagy.
From: Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging
Age-associated mitochondrial malfunction leads to mtDNA release triggering cGAS/STING activation and type I IFN response in mice and humans. Restoring mitochondrial homeostasis using UA constrained mtDNA leakage, reduced inflammation and improved healthspan. Created with BioRender.com.
