Fig. 1: Sm-TCR Treg mechanisms of action.
From: Smith-specific regulatory T cells halt the progression of lupus nephritis
Sm-TCR Tregs act through a variety of mechanisms to suppress autoreactivity and restore immune tolerance. Tregs can suppress autoreactive B cells and autoantibody production, suppress pathogenic T cells, tolerize antigen-presenting cells such as dendritic cells, and can directly lyse inflammatory cells. TCR transduction of a Sm-specific TCR renders the Treg more potent in its ability to specifically suppress lupus nephritis. Created with BioRender.com.
