Fig. 2: Immunodominant antigens in ATB. | Nature Communications

Fig. 2: Immunodominant antigens in ATB.

From: Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection

Fig. 2

A Number of open reading frames (ORFs) corresponding to recognized epitopes by each participant. Each dot represents one participant, n = 21, median ± interquartile range is shown. B Distribution of recognized ORFs per protein category. C The identified antigens (black bars) were divided into protein categories (Mycobrowser) and compared to the H37Rv genome (grey bars). Chi-square test (two-sided). D Antigenic islands identified by a 5-gene window spanning the H37Rv genome. ATB (black) compared to healthy IGRA+ (orange22,). E Proteins within each antigenic island, % of total response per antigen across the proteome-wide screen. ATB (black bars) and healthy IGRA+ (orange bars). Source data are provided as a Source data file.

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