Fig. 4: T cell responses specific for different protein categories. | Nature Communications

Fig. 4: T cell responses specific for different protein categories.

From: Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection

Fig. 4

A Frequency of cytokine-producing, IFNγ, TNFα, and IL-2, CD4 T cells in response to PC85, PC71, and MTB300. B Frequency of cytokine-producing, IFNγ, TNFα, and IL-2, CD8 + T cells in response to PC85, PC71, and MTB300. C Percentage pool-specific IFNγ, TNFα, and IL-2 production by CD4 T cells expressing each of the seven possible combinations. D Pie charts representing single, dual and triple cytokine producing CD4 T cells. Each section of the pie chart represents a specific combination of cytokines, as indicated by the color. E–G Proportion of CCR7 + CD45RA- (central memory), CCR7-CD45RA- (effector memory), CCR7 + CD45RA+ (naïve), and CCR7-CD45RA+ (TEMRA) T cells for each peptide pool. E IFNγ, (F) IL-2, (G) TNFα. (A–C, E–G) Each point represents one participant from the Peruvian cohort (mid-treatment), n = 10, median ± interquartile range is shown. Kruskal Wallis with Dunn’s multiple comparison test (two-sided) was used for comparison. Source data are provided as a Source data file.

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