Fig. 5: Cytokine response against the ATB-specific peptide pool, ATB116. | Nature Communications

Fig. 5: Cytokine response against the ATB-specific peptide pool, ATB116.

From: Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection

Fig. 5

A Magnitude of response (total SFC for IFNγ) against ATB116 (red) and MTB300 (white) in ATB (at diagnosis; n = 24), IGRA+ (n = 25), and IGRA- (n = 43) from Sri Lanka. B Frequency of cytokine-producing, IFNγ, TNFα, and IL-2, CD4 T cells in response to ATB116 and MTB300 in ATB (at diagnosis, n = 9; grey) and IGRA- (n = 9; blue) participants. C Magnitude of response (total SFC for IFNγ) against ATB116 (red) and MTB300 (white) in ATB (at diagnosis; n = 9), ATB (mid-treatment; n = 12), IGRA+ (n = 52), and IGRA- (n = 26) household contacts from Moldova. A–C Each dot represents one participant, median ± interquartile range is shown. Kruskal Wallis with Dunn’s multiple comparison tests (two-sided) was used to compare IFNγ response among ATB, IGRA + , and IGRA- (A, C). Mann Whitney test (two-sided) was used to compare cytokine levels in ATB and IGRA- (B). A, C The dashed line indicates the cut-off used for a positive response (50 SFC/106 PBMCs). Source data are provided as a Source data file.

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