Fig. 3: Identification of the largest module containing genes that are found in the same community in a range of modularity resolution (Methods). | Nature Communications

Fig. 3: Identification of the largest module containing genes that are found in the same community in a range of modularity resolution (Methods).

From: Rare disease research workflow using multilayer networks elucidates the molecular determinants of severity in Congenital Myasthenic Syndromes

Fig. 3

In each module, genes are connected if they are found in the same multilayer communities at n values of the resolution parameter γ within the range under consideration (γ ∈ (0,4]). The arrows indicate the systematic increase of n. At n = 8, the module contains genes that are always found in the same community in the entire range of resolution (see Supplementary Information, Multilayer community detection analysis). The largest module containing the CMS linked gene set (highlighted in red), which includes known CMS causal genes, severe-specific heterozygous compound variants and CNVs, is shown. Source data are provided in the Github repository of the project (see Data Availability section).

Back to article page