Fig. 4: XPO1 inhibition induces tumor regression in primary mouse model of MYC-induced HCC.
From: Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma
a Representative MRI scans of liver tumors in LAP-tTA/tet-O-MYC/FVB/N mice treated with vehicle or Selinexor (3 doses per week for two weeks). The tumor nodules are indicated by white or red arrows. b, c Absolute and relative fold changes in liver tumor volume in LAP-tTA/tet-O-MYC/FVB/N mice treated with vehicle (n = 4 mice) or Selinexor (n = 6 mice). In (c), lines represent means which were compared using two-tailed Student’s t-test. d–f Immunofluorescence staining and quantification of phospho-histone H3 and cleaved-caspase 3 in liver tumors of mice after short-term treatment with vehicle or Selinexor (3 doses per week, one week). Cell nuclei were counterstained with 4’,6-diamidino-2-phenylindole (DAPI). The histology of tumors (T) and adjacent normal liver tissues (N) are shown by hematoxylin and eosin staining. Scale bars = 50 μm. Samples were collected from at least three mice in each group. Bars in (e, f) represent means of n = 8 high-power fields (HPFs) of one representative biological sample, error bars represent SEM, p-values were determined using two-tailed Student’s t-test. For this figure, source data are provided as a Source Data file.
