Fig. 2: Phylogenetic relationships, domain architectures, and reactions catalyzed by FAA hydrolase family enzymes. | Nature Communications

Fig. 2: Phylogenetic relationships, domain architectures, and reactions catalyzed by FAA hydrolase family enzymes.

From: A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle

Fig. 2

A Phylogram of representative FAH family enzymes. Nodes with bootstrap values ≥0.5 are shown. Typical architectures of each subfamily of enzymes is shown with conserved domains colored as indicated. Reactions catalyzed by each subfamily of enzymes is shown with enol-keto tautomers highlighted. BS Bacillus subtilis, Mm Methanococcus maripaludis, Dr Danio rerio, Hs Homo sapiens, Sc Saccharomyces cerevisiae, Ec Escherichia coli, Dm Drosophila melanogaster, Ce Caenorhabditis elegans, At Arabidopsis thaliana, Ss Saccharolobus solfataricus. B Predicted FAHD genes (colored blue) cluster with predicted L2HGDH (colored orange) and/or D2HGDH (colored purple) genes in various configurations in several diverse prokaryotic genomes. Apparently unrelated genes are colored white.

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