Fig. 5: NELF-B and TDP-43 are required for the proper maturation of germ cells. | Nature Communications

Fig. 5: NELF-B and TDP-43 are required for the proper maturation of germ cells.

From: RNA polymerase II pausing is essential during spermatogenesis for appropriate gene expression and completion of meiosis

Fig. 5

a UMAP representation of all 10 somatic and germ cell type clusters, integrated across the 3 genotypes (n = 24,269 cells). b Cell clusters from (a), separated by genotype. (Control: n = 11,170, NELF-B cKO: n = 6404, TDP-43 cKO: n = 6695 cells). c Numbers of each germ cell type and somatic Sertoli cells per genotype. Cell counts were normalized by the number of mice per genotype (Control: n = 4, NELF-B cKO: n = 2, TDP-43 cKO: n = 3). Source data are provided as Source Data Fig. 5.

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