Fig. 4: The feature of head domain of LayV-G and structure alignment with several HNVs.
From: The cryo-EM structure of homotetrameric attachment glycoprotein from langya henipavirus
a The left panel shows the top view from a vertical direction of the viral membrane (PDB ID:8JZB). The middle panel displays the side view, while the right panel depicts the bottom view of the head domain of LayV-G. The head domain is colored in a gradient from light blue, green, to red, representing the N-terminus to C-terminus orientation. Two special tips of blade4 and blade5 were boxed by a green and a purple dotted line boxed, respectively. Cysteine residues that form disulfide bonds in two tips are shown as sticks and labeled. b A structure alignment is performed with five typical HNVs attachment glycoprotein. The alignment includes MojV (colored in gray, PDB ID: 5NOP), HeV (colored in light pink, PDB ID: 2VSK), NiV (colored in deep green, PDB ID: 2VWD), GhV (colored in green, PDB ID: 4UF7), and CedV (colored in orange, PDB ID: 6P7Y).The green and purple dotted line boxes exhibit the special tips at the head domain of blade4 and blade5 in LayV-G are almost identical to those in MojV, and different from HeV, NiV, GhV and CedV.
