Fig. 1: Importance of macrolactones and the enantioselective synthesis.
From: Carbene organic catalytic planar enantioselective macrolactonization
A Examples containing macrolactone motif and representative planar chiral macrocycles; B Typical synthetic strategy via macrolactonization; C Preparation of planar chiral macrolactones by enzyme catalysis; D Our proposed carbene organocatalytic strategy for planar enantioselective macrolactonization.
