Fig. 5: Regional association plots for the APOB region. | Nature Communications

Fig. 5: Regional association plots for the APOB region.

From: Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping

Fig. 5

Association of the detection of the alternate variant peptide TSQCILK of APOB (pc2, nanoparticle 1) with the presence/absence of the matching genetic variants at the APOB locus (top), GWAS associations of Apolipoprotein B (middle) and LDL-cholesterol (bottom) measured by clinical biochemistry methods in blood samples from 343,621 participants of the UK Biobank study. The highlighted variant rs1367117 (chr2:21263900) is the MS-PAV in TSQC[T/I]LK. Linkage (LD) between variants is indicated color, gene positions are below. P-values (unadjusted) are from linear models generated by the respective studies.

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