Table 1 MS-pQTLs

From: Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping

Gene

UniProtID

rsid

SNP

MAF

p-value

beta

cis-pQTL

MST1

G3XAK1

rs3197999

3:49721532:G:A

23.4%

2.6E-18

−0.716

Both

ITIH1

P19827

rs1042779

3:52821011:A:G

37.7%

1.2E-11

0.545

Both

KNG1

P01042

rs2304456

3:186445052:T:G

16.0%

4.8E-21

0.911

SomaScan

HLA-C

A2AEA2

rs707908

6:31238053:G:C

21.8%

2.0E-10

0.630

None

CFB

B4E1Z4

rs12614

6:31914179:C:T

18.5%

1.2E-13

−0.590

Both

PON1

P27169

rs662a

7:94937446:T:C

37.4%

4.6E-09

−0.424

Olink

PON1

P27169

rs854560a

7:94946084:A:T

27.4%

2.7E-10

0.499

Olink

PON2

A0A0J9YXF2

rs12026

7:95041016:G:C

30.6%

1.3E-36

−0.998

Olink

FGL1

Q08830

rs3739406

8:17739538:T:C

49.2%

1.8E-11

0.512

Both

GALC

G3V255

rs34362748

14:88442712:C:T

11.5%

1.0E-15

0.887

None

SERPINA10

G3V2W1

rs2232700

14:94756450:T:A

30.8%

1.5E-22

0.741

SomaScan

SERPINA1

P01009

rs709932

14:94849201:C:T

23.1%

3.8E-08

0.431

Both

DSC3

Q14574

rs276938b

18:28610988:C:T

41.4%

2.1E-08

−0.422

None

DSC3

Q14574

rs276937b

18:28611061:A:T

41.2%

1.5E-08

−0.429

None

  1. Associations of MS-PAVs that are significantly (p < 5 × 10−8) associated with protein levels derived using the PAV-exclusive library; detection of a cis-pQTL on the SomaScan and/or Olink platform is indicated.
  2. acorrelation between rs662 and rs854560 is r2 = 0.20.
  3. bcorrelation between rs276938 and rs276937 is r2 = 0.99.