Table 3 MS-PAVs that overlap with disease-relevant GWAS hits

From: Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping

Gene

UniProtID

rsID

Fisher P

Peptide

GWAS trait

WDR1

O75083

rs13441

4.8E-37

FTIGDHSR

Atrial fibrillation and flutter

PIP4K2A

H7BXS3

rs2230469

2.2E-48

IYIDDNSK

Body fat composition

CHID1

Q9BWS9

rs6682

5.9E-59

MVWDSQASEHFFEYK

Body mass index

SCFD1

A0A7I2V362

rs229150

1.8E-28

FGQDIISPLLSVK

Amyotrophic lateral sclerosis

SPTB

P11277

rs229587

9.6E-14

ETWLNENQR

Red blood cell phenotypes

LOXL1

H3BUV8

rs1048661a

1.0E-70

EVAVGDSTGMALAR

Exfoliation glaucoma

LOXL1

H3BUV8

rs3825942a

5.5E-57

HGDSASSVSASAFASTYR

Coronary artery disease, Exfoliation glaucoma

GIP

P09681

rs2291725

1.2E-22

ALELAGQANR

Coronary artery disease, Type II diabetes

  1. Selected MS-PAVs that have not been reported as cis-pQTLs in previous pQTL studies and that overlap with a clinically relevant GWAS catalog entry (edited for brevity, see Supplementary Data 3 for details).
  2. acorrelation between rs1048661 and rs3825942 is r2 = 0.12.
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