Fig. 5: Ageing controls the selective secretion of miRNAs.
From: Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans
a Ageing regulates miRNA levels in the extracellular vesicles (EVs) of worms. MiRNAs with a P value smaller than 0.05 and a fold of change (FC) bigger than 1.5 were considered significantly changed during ageing. Two-sided t-test without adjustments for multiple comparisons. b The relative abundance of the indicated miRNAs in the whole worm (worm) and EV from samples collected on day 1 and day 8 of adulthood. Three biological replicates were shown. c EV loading ratio of the indicated miRNAs at day 1 and day 8 of adulthood. PITT-miRs detected in EV are highlighted in green in b and c.
