Fig. 2: Metastasis requires no additional CNVs or cancer driver gene mutations.

a Dot plot showing the CNVs imputed by WGS in primary teratoma (P, n = 6 biological independent samples) and metastatic (Met, n = 6 biological independent samples) samples. WT ESCs were used as the control. The gray bars indicate the interquartile ranges. The thick horizontal lines indicate segmented values. Trisomic chromosomes are indicated in red. Chr, chromosome. WES revealed the somatic mutations arising during metastasis (b–g, n = 7 biological independent samples). Bar chart displaying the total number of variant classifications (b), variant types (c), and SNV classes (d) identified in metastatic samples. e Bar plot showing the variant number and variant classifications detected in each metastatic sample. f Box plot showing the number of variant classifications. Data are median (line within the box) with a SD (box limit) and 1.5 × outliers (whiskers). g Bar plot showing the frequency of gene mutations in metastatic samples. Top 10 mutated genes were presented. Colors were used to represent the variant classification (b, e–g).