Fig. 2: The loss of TcrXY signalling attenuates Mtb survival during chronic infection. | Nature Communications

Fig. 2: The loss of TcrXY signalling attenuates Mtb survival during chronic infection.

From: TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infection

Fig. 2

Growth and survival of the ΔtcrXY mutant in the lungs, spleens, and livers of female C57BL/6 mice following low-dose aerosol infection. The infectious dose was confirmed from two mice from each group on day 1. Each time point represents the mean recovered CFU from each organ from five mice (except week 16 which represents four mice in the ΔtcrXY group), with error bars denoting SD. Statistical analysis was performed using an unpaired two-tailed t-test at week 16. Source data are provided as a Source Data file.

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