Fig. 1: Reduced proportions of β7⁺ peripheral memory T cells in Crohn’s disease.

Representative (left) and quantitative (right) flow cytometry of α4, β7 and β1 expression on peripheral blood CD4⁺ (A) and CD8⁺ (B) memory T cells (Tmem) (CD3⁺TCRVα7.2⁻CD4⁺CD8a⁻CD45RA⁻ and CD3⁺TCRVα7.2⁻CD4⁻CD8a⁺CD45RA^lo/neg, respectively). n = 14–27 patients with Crohn’s disease (CD) or non-IBD controls (CON). Significant outliers were detected by 1% ROUT test and removed from analysis. Normality was determined by D’Agostino and Pearson test and two-tailed unpaired t or Mann–Whitney tests were performed accordingly. Data are displayed as box-whisker plots from minimum to maximum. The center line indicates the median with box limits defining the quartiles. Source data are provided as a Source Data file.