Fig. 5: In vivo evaluation of the PAX6-associated UCNE. | Nature Communications

Fig. 5: In vivo evaluation of the PAX6-associated UCNE.

From: Multi-omics analysis in human retina uncovers ultraconserved cis-regulatory elements at rare eye disease loci

Fig. 5

a This UCNE displays reporter activity in the human embryonic forebrain (6/9 embryos) as well as in other structures including eye (3/6 embryos) and neural tube. Figure obtained from the VISTA enhancer browser (hs855). b Zebrafish enhancer assays (n = 2, see also Supplementary Data 10) at 3 different time points (1 dpf, 2 dpf, 3 dpf) showing GFP-positive tissues (optic fissure −1 dpf-, lens cells −2,3 dpf-, and forebrain −2,3 dpf-; white arrows). dpf days post-fertilization.

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