Fig. 2: Disulfide-stabilized S2 crystallized in an open prefusion conformation. | Nature Communications

Fig. 2: Disulfide-stabilized S2 crystallized in an open prefusion conformation.

From: Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge

Fig. 2

a Side (left) and top (right) views of the crystal structure for HexaPro-SS-Δstalk are shown in ribbons. The cysteine substitutions (inset) from symmetry mates are in proximity to each other to form disulfide bonds, but Glu957 does not form a salt bridge with Arg765 from the neighboring protomer. b The side and top view of HexaPro-SS-Δstalk presents a prefusion conformation with the trimer apex splayed open. c The surface representation of HexaPro (PDB ID: 6XKL) with the S1 subunit removed, exhibiting a closed prefusion conformation.

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