Fig. 2: Effect of aggregating variants on RV heritability estimates.
From: A method to estimate the contribution of rare coding variants to complex trait heritability
a Comparison of RV heritability estimates derived from aggregation of variants in gene-burden blocks, exome-wide blocks (blocks of 5000 unaggregated variants) and gene-wise blocks with un-aggregated variants. The y-axis corresponds to the rare coding variant contribution to percentage of heritability estimates for each trait. b Correlation between heritability estimates from gene-wise blocks represented on the y-axis versus exome-wide blocks, represented on the x-axis.
