Fig. 5: Manhattan plot illustrating genes with significant heritability for selected traits.
From: A method to estimate the contribution of rare coding variants to complex trait heritability
RARity was used to determine h2RV-gene for all genes with qualifying RVs. Each dot represents a single gene, with genes ordered on the x-axis according to their genomic position. The y-axis represents the significance of h2RV-gene measured as -log10 transformed p-values, where the p-values were derived using F-test. Red, horizontal dashed lines mark the Bonferroni’s p-value significance threshold corrected for 18,214 genes (p-value < 2.75 × 10−6). Genes with significant h2RV-gene are labelled.
