Table 1 Characteristics of the ART and SC individuals included in this study

From: Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight

 

ART

SC

P-value

(N = 270)

(N = 181)

 

% (N)

 

Source material

Blood1

38.1% (103)

35.9% (65)

 

   Newborns

17.0% (46)

0.0% (0)

 

   Young adults

21.1% (57)

35.9% (65)

 

Placenta2

24.4% (66)

28.2% (51)

 

Buccal cells3 & Saliva2

37.4% (101)

35.9% (65)

 

   Children

37.4% (101)

2.8% (5)

 

   Young adults

0.0% (0)

33.1% (60)

 

Mother-child pairs

67

90

 

Clinical parameters

Mean maternal age4 ± SD*

32.5 ± 3.7 (211)

30.1 ± 4.4 (173)

<0.0001a

Maternal BMI > 25*

40.2% (86/214)

25.6% (42/164)

0.0031b

Birthweight*

(224)

(164)

 

   Mean (grams) ± SD

3377.9 ± 536.0

3394.3 ± 500.7

0.7596a

   <10th percentile

7.0% (19)

5.0% (9)

0.2407b

   <25th percentile

15.2% (41)

14.4% (26)

0.4992b

Preterm birth (<37 weeks)*

5.8% (13/224)

6.1% (10/164)

1.0000b

Sex*

(224)

(181)

 

 (Male–Female)

41.5% (112) –41.5% (112)

44.8% (81) –55.2% (100)

0.3176b

Culture medium

224

NA

 

   Vitrolife® G3

19.3% (52)

NA

 

   Vitrolife® G5

24.4% (66)

NA

 

   Cook®

18.1% (49)

NA

 

   UZB

21.1% (57)

NA

 

   Unknown

17.0% (46)

NA

 

Pregnancy hypertension*

4.1% (8/193)

1.9% (3/159)

0.3571b

Gestational diabetes*

1.0% (2/193)

1.3% (2/158)

1.0000b

Primiparity*

75.2% (167/222)

47.2% (68/144)

<0.0001b

Smoking during pregnancy*

5.5% (12/220)

7.7% (13/169)

0.4086b

  1. The donors were recruited in different centres: 1UZ Brussel, Belgium, 2Maastricht University Medical Center, The Netherlands and 3Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Belgium. 4Age in years.
  2. ART assisted reproductive technologies, SC spontaneously conceived, SD standard deviation, BMI body mass index.
  3. *Only a subset of samples was provided with clinical data such as maternal age, maternal BMI (body mass index), birthweight (categorized in percentiles), gestational age, sex, culture medium, complications during pregnancy and parity. UZB medium was an in-house medium made in the UZ Brussel. All individuals are singletons from fresh embryo transfers. Some characteristics were not applicable (NA) for some samples. N indicates the number of samples for which this data was available. Two-sided Statistical tests were performed using the student t test (a) or the Fisher’s exact test (b).