Table 4 Discriminant analysis to predict a birthweight under the 25th percentile in SC and ART individuals exposed to Vitrolife® culture medium

From: Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight

Factors included in model

Standardized Canonical Discriminant Function Coefficients

Wilks’ Lambda

N = number of cases included in the model

Correctly classified (original vs cross-validated grouped cases)

Correctly classified in each category

All pregnancy-related factors

Maternal age

0.871

P = 0.174

N = 200

62.5% vs 59.5%

63.3% >P25 correct

58.1% <P25 correct

Smoking

0.412

Pregnancy hypertension

0.392

Maternal BMI > 25

−0.109

Primiparity

0.132

Gestational diabetes

−0.093

mtDNA factors only

Homoplasmic tRNA variants

0.369

P < 0.001

N = 282

64.9% vs 64.9%%

64.5% >P25 correct

66.7% <P25 correct

Heteroplasmic non-synonymous and rRNA variants

0.681

Haplogroup I

0.411

Haplogroup J

0.343

Haplogroup T

−0.398

Pregnancy and mtDNA factors

Maternal age

0.565

P < 0.046

N = 200

68.5%% vs 63.0%

68.6% >P25 correct

67.7% <P25 correct

Smoking

0.326

Pregnancy hypertension

0.217

Maternal BMI > 25

−0.102

Gestational diabetes

−0.022

Primiparity

0.115

Homoplasmic tRNA variants

0.333

Haplogroup I

0.218

Haplogroup J

0.236

Haplogroup T

−0.325

Heteroplasmic non-synonymous and rRNA variants

0.531