Fig. 1: γδ T cells were activated and expanded in the tumor upon pembrolizumab treatment in a complete responder MCC patient. | Nature Communications

Fig. 1: γδ T cells were activated and expanded in the tumor upon pembrolizumab treatment in a complete responder MCC patient.

From: Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient

Fig. 1

Single cell suspensions of tumor core biopsies from MCC patients were evaluated by flow cytometry. A Flow cytometry analysis of γδ T cells in baseline and week 9 tumor biopsies from the complete responder patient E-013 is shown. B Quantification of γδ T cell frequency as measured by flow cytometry in tumor biopsies from six MCC patients. Red denotes partial response (PR)/complete response (CR), blue represents progressive disease (PD). Each individual patient is marked by different symbols as shown. Data for on-treatment biopsy samples from patient E-020 and E-033 were unavailable due to insufficient tumor material. Source data provided as a source data file. C Lymphocytes from baseline biopsies of four MCC patients were evaluated for PD-1 and TIGIT expression and gated on CD8, CD4 and γδ T cells.

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