Fig. 5: Hybrid aerogels also promote collagen deposition after subcutaneous implantation. | Nature Communications

Fig. 5: Hybrid aerogels also promote collagen deposition after subcutaneous implantation.

From: Mechanically resilient hybrid aerogels containing fibers of dual-scale sizes and knotty networks for tissue regeneration

Fig. 5

a Trichrome staining images of the native subcutaneous tissue. b, c Trichrome staining images of different cross-sections of explants after implantation for 14 and 28 days. The blue color indicates the deposited collagen area. Twelve tissue samples were used for histology staining and similar results were obtained. d Percentages of the deposited collagen area in each explant. e Quantification of the deposited collagen in each explant. Data are presented as mean values ± SD, N = 5 (randomly selected 5 tissue samples). The significant difference was detected by two-way ANOVA with Tukey’s multiple comparisons test. The ‘ns’ indicated no significant difference, *p  <  0.01, **p  <  0.001, ***p  ≤  0.0006, ****p <  0.0001. Scale bar = 50 µm. 2D NF mat nanofiber mat, NFA nanofiber aerogels coated with 1% gelatin, MFA microfiber aerogels coated with 1% gelatin, NF/MF-A1 hybrid aerogels containing NF/MF at a ratio of 50:50 (w/w) coated with 1% gelatin.

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