Fig. 2: Macrophage depletion promotes leukaemogenesis. | Nature Communications

Fig. 2: Macrophage depletion promotes leukaemogenesis.

From: Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche

Fig. 2

a Schematic overview of macrophage depletion following CSF1R blockage in CML chimeric mice. Mice were treated with anti-CSF1R antibody or IgG2a isotope control one day prior to tetracycline withdrawal. Anti-CSF1R was then administered 3 times per week. Schematic created with BioRender.com (Agreement number: FA268HUUTO). b Percentage of CD11b+F4/80+ cells in CD45.1 or CD45.2 BM following treatment with anti-CSF1R (n = 3 mice) or IgG2a isotope control (n = 4 mice). c–e Overall survival (c) and myeloproliferation in blood (d) and BM (e) at experimental endpoint following treatment with anti-CSF1R (n = 5 mice) or IgG2a isotope control (n = 4 mice). The control (CTR) experimental arm (n = 3 mice) refers to irradiated control mice. Data are shown as the mean ± s.e.m. P-values were calculated using unpaired two-tailed t-test (b, d, e), or log-rank (Mantel–Cox) test for survival analysis (c). Source data are provided as a Source Data file.

Back to article page