Fig. 7: LTF exposure alters the clearance function of human macrophages.

a Quantification of clearance of apoptotic cells in human BMDM exposed to CM, CM in the presence of 50 μM SSO or 50 μg/mL LTF, or LCM for 24 h (n = 4 independent experiments). b Percentage of CTV/CD11b^high THP-1-derived macrophages following a 24 h exposure to 50 μM SSO, 50 μg/mL LTF, or a combination of both (n = 6 independent experiments). c Quantification of phagocytosis of latex beads in THP-1 macrophages treated with 50 μM SSO, 50 μg/mL LTF, or a combination of both (n = 5 independent experiments). d Surface marker expression of CD36 in CM or LCM exposed THP-1-derived macrophages for 24 h (n = 4 independent experiments). e Expression of CD36 in untreated (UT) THP-1 macrophages or exposed to 50 μg/mL LTF (n = 4 independent experiments). f Percentage of CTV/CD11b^high THP-1 control (CTR) or CD36 KO macrophages treated with 50 μM SSO or 50 μg/mL LTF for 24 h (n = 4 independent experiments). g Expression of CD11b in THP-1-derived macrophages treated with 50 μM SSO or 50 μg/mL LTF, or a combination of both for 24 h (n = 4 independent experiments). h Quantification of CD11b MFI in THP-1 CTR or CD36 KO macrophages incubated with 50 μM SSO or 50 μg/mL LTF for 24 h (n = 4 independent experiments). Data are shown as the mean ± s.e.m. P-values were calculated using ordinary one-way ANOVA with Dunnet’s multiple comparisons test (a–c, f–h), and unpaired two-tailed t-test (d, e). Source data are provided as a Source Data file.