Fig. 5: In-cell interaction of functional human SINE element FRAM with rRNA. | Nature Communications

Fig. 5: In-cell interaction of functional human SINE element FRAM with rRNA.

From: Decryption of sequence, structure, and functional features of SINE repeat elements in SINEUP non-coding RNA-mediated post-transcriptional gene regulation

Fig. 5

a Regions of 18S rRNA found to pair with the SINEUP FRAM region in PARIS2 data. b Corresponding interacting regions (Int) to (a) are highlighted on FRAM RNA. c Description of FRAM-18S rRNA pairs and interaction sites marked in (a) and (b). d 28S rRNA regions identified as FRAM interaction sites by PARIS2 and e their corresponding binding regions on FRAM. f Details of FRAM-28S rRNA interactions highlighted in (d) and (e). Different interaction sites (Int) are represented by different colors. Possible base-pairing based on sequence complementarity of RNA–RNA pairs is shown in (c) and (f). In (b) and (e) the icSHAPE-guided FRAM structure from whole-cell lysate is shown. Matching regions to SINEUP motifs from M1 to M7 are indicated by dashed squares.

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