Fig. 3: RAN translation in DM2 fibroblasts. | Nature Communications

Fig. 3: RAN translation in DM2 fibroblasts.

From: Chronic endoplasmic reticulum stress in myotonic dystrophy type 2 promotes autoimmunity via mitochondrial DNA release

Fig. 3

a schematic representation of the repeat associated non-ATG (RAN) translation. b protein concentration of LPAC in DM2 (n = 9) and control (n = 7) fibroblasts was determined by immunoblotting. c, d immunohistochemistry (IHC) showing representative LPAC (red) and QAGR (brown) immunostaining in skin section in healthy control and DM2, as well as quantification of staining in healthy controls (n = 8) and DM2 patient (n = 7) samples. b is representative for 9 DM2 patients. c, d include data from one independent experiment. Data are shown as mean ± SD. Statistical significance was assessed using student’s t test (c) or Mann-Whitney U test (b, d).

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