Table 1 Clade-specific variants identified for GB-WLS.C2

From: Genomic epidemiology reveals geographical clustering of multidrug-resistant Escherichia coli ST131 associated with bacteraemia in Wales

Position in EC958

EC958a

GB-WLS.C2 Welsh Clustera

Changeb

Impact

Codon

Gene

Product

601,912

C

T

Syn

LOW

383

cusB

Cation efflux system protein

632,160

C

T

Q = >stop

HIGH

130

fepE

Ferric enterobactin transport

1,672,896

T

C

Syn

LOW

130

dosP

Oxygen sensor protein

2,698,528

G

A

T = > I

MODERATE

232

fryC

Fructose-like permease IIC component

2,902,622

T

C

     

2,964,604

A

G

Syn

LOW

165

pncC

Nicotinamide-nucleotide amidohydrolase

  1. aEmboldened and italicised nucleotides are specific to sub-clade C2 EC958 and isolates within the Welsh cluster, respectively.
  2. bConsequence of SNP relative to EC958 (C2).
  3. bSynonymous change (Syn); non-synonymous changes to protein-coding genes are shown by single letter amino acid abbreviation (EC958 sequence on the left, SNP impact on right); blank lines indicate variant in intergenic region.
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