Fig. 6: HCMV-NG exposed moDCs can be traced back to three distinct clusters as identified in mock-treated moDCs. | Nature Communications

Fig. 6: HCMV-NG exposed moDCs can be traced back to three distinct clusters as identified in mock-treated moDCs.

From: Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells

Fig. 6

Heat maps showing the average expression per cluster (log2-fold change vs. the grand mean) of marker genes that were common in mock-treated and HCMV-NG exposed cells of donor #1 (a) and donor #2 (b). Alluvial charts showing the contribution of mock-treated moDCs to HCMV-NG exposed clusters of donor #1 (c) and donor #2 (d). e Donor integration by canonical correlation analysis of M1, M2, and M3 clusters. The same UMAP embedding is shown for each of the three mock-treated clusters with donors highlighted. f Pathway analysis of manually selected DC characteristics pathways for the different clusters using gene set variation analysis (GSVA). Positive GSVA scores indicate an enrichment of strongly expressed genes in a pathway.

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