Fig. 2: RFP-loaded LSC-Exo has superior distribution in mouse lung.
From: Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2
a Study scheme of RFP-Exo’s distribution in mice, created with Biorender.com. b 2, 4 and 24 h ex-vivo imaging of mouse lungs after RFP-Exo, RFP-HEK or RFP-Lipo nebulization. c Quantitative results of RFP intensity in ex-vivo mouse lungs; n = 3. d Representative immunostaining images for whole lung, trachea, bronchioles, and parenchyma. Exosomes (red) or liposomes (red), phalloidin (green) and DAPI (blue). Scale bar, 1000 μm for whole lung, 100 μm for parenchyma. e Quantification results of RFP fluorescence density in trachea, bronchioles, and parenchyma; n = 3 per group. Data are mean ± s.d. The one-way ANOVA with Bonferroni correction was performed for statistical analysis. Source data are provided as a Source Data file.
