Fig. 4: Mutations occurring over time in viral sequences. | Nature Communications

Fig. 4: Mutations occurring over time in viral sequences.

From: Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients

Fig. 4

a Number of transition and transversion mutations in molnupiravir-treated (purple) and Usual Care (grey) participants. Transition mutations (G to A, A to G, C to T and T to C) are shown as solid lines, transversions (G to C, C to G, A to T, C to A, G to T, T to G and T to A) are shown as dotted lines; standard deviation denoted by error bars. b Shannon entropy over time in participants receiving molnupiravir or Usual Care. Participants in each group with viral loads above the LLOQ by day 14 (Molnupiravir Persistent; purple and Usual Care Persistent; orange) and participants with <LLOQ viral loads by Day 14 (Molnupiravir Resolved; grey or Usual Care Resolved; yellow) are shown; standard deviation denoted by error bars. b Shannon entropy over time in participants receiving molnupiravir or Usual Care. Participants in each group with viral loads above the LLOQ by day 14 (Molnupiravir Persistent; purple and Usual Care Persistent; orange) and participants with <LLOQ viral loads by Day 14 (Molnupiravir Resolved; grey or Usual Care Resolved; yellow) are shown. c Numbers of sequenced samples at each time point. Source data are provided as a Source Data file.

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