Fig. 1: Schematic illustration of ultrasmall AuPd alloy nanozymes mimicking the SOD-MPO enzymatic cascade killing function of neutrophils for tumor catalytic therapy.
From: Ultrasmall metal alloy nanozymes mimicking neutrophil enzymatic cascades for tumor catalytic therapy
Ultrasmall metal nanozymes with different alloy ratios are synthesized. These nanozymes exhibit alloy ratio-dependent SOD and MPO-like activities, among which the Au1Pd3 alloy nanozymes present the highest cascade activity. The Au1Pd3 alloy nanozymes mimic the SOD-MPO cascade enzymatic therapy performed by neutrophils, demonstrating effective tumor therapy by inducing DNA damage and cell apoptosis via producing HClO and 1O2.
