Fig. 6: Tumor cell death mechanism induced by Au1Pd3 alloy nanozymes.
From: Ultrasmall metal alloy nanozymes mimicking neutrophil enzymatic cascades for tumor catalytic therapy
a Morphology of CT26 cells treated with PBS and Au1Pd3 nanozymes. The blue and red arrows indicate the microvilli and condensed nuclear chromatin, respectively. The red box refers to the apoptotic body. Scale bars = 4 µm. b Confocal microscopy images of CT26 cells treated with different concentrations of Au1Pd3 nanozymes using γ-H2AX as a DNA damage biomarker. Scale bar = 50 µm. c Data analysis of flow cytometry assays on cell cycles of cells treated with Au1Pd3 nanozymes (n = 3 independent experiments). P values are determined with two-way ANOVA Tukey’s multiple comparisons test. d Data analysis and (e) flow cytometry results of Annexin V-FITC/PI assay on CT26 cells treated with Au1Pd3 nanozymes (n = 3 independent experiments). P values are determined with one-way ANOVA Tukey’s multiple comparisons test. All data are presented as mean ± STD. Source data are provided as a Source Data file.
