Fig. 7: Model depicting dephosphorylation mediated regulation of PLK1 by EYA4/EYA1. | Nature Communications

Fig. 7: Model depicting dephosphorylation mediated regulation of PLK1 by EYA4/EYA1.

From: The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Fig. 7

G2, Phosphorylation of the putative PDS on EYA4/EYA1 (S128 on EYA4) allows for interaction with PLK1 and dephosphorylation of pY445 within the PBD. G2→Prophase, Dephosphorylation of pY445 changes the structure of the PLK1 PBD, favouring the interaction between PLK1 and PLK1 activation complex members, and permitting greater levels of pT210 phosphorylation by AURKA. Prophase, Active PLK1 supports centrosome maturation and separation in preparation for mitotic spindle formation. Prophase→Successful Mitosis, Accurate and timely completion of mitosis. Alternatively, EYA4/EYA1 loss or EYA inhibition causes mitotic aberrations, increased mitotic duration, and mitotic cell death. Created with biorender.com.

Back to article page