Fig. 5: Relationship between SG formation and glycolytic properties of hOLs.
From: Regulation of stress granule formation in human oligodendrocytes
A Time course experiment showing hOLs exposed to Ctrl or NG conditions, in the presence or absence of 2DG (n = 4 independent biological replicates) or CP (n = 4 independent biological replicates). The percentages of SG-positive cells were assessed by G3BP1. Statistical differences are shown here between NG and NG+drug groups. B ATP levels in hOLs cultured for 4 h in Ctrl or NG conditions with or without 2-DG or CP agents. The luminescence (ATP) of each condition was normalized per cell (n = 3). Graphs displays arbitrary units (arb. units). Each dot in the graphs corresponds to an independent biological replicate. Statistical analyses were performed between Ctrl and Ctrl+drug or NG and NG+drug groups. All data are expressed as mean values ± SEM, analyzed by one-way ANOVA followed by Bonferroni’s multiple comparisons correction. All significant P-values are indicated; ns or unlabeled not significant. Ctrl optimal media, NG no glucose. Source data are provided as a Source Data file.
