Fig. 7: Model summarizing our findings.
From: PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
Model summarizing our findings. We propose that PAF1c acts downstream of MYC to enhance full-length transcription of long DNA repair genes while limiting the expression of short MHC class I genes. Interference with PAF1c function results in the redistribution of transcription elongation factors, including SPT6. This restores expression of short MHC class I genes and impairs the full-length transcription of long DNA repair genes. This change reshapes the tumor microenvironment, causing immune cell-dependent tumor regression and enabling long-term survival of PDAC-bearing mice.
