Fig. 2: Mouse xenograft assay shows that the MPI fibroblasts expressing oncogenic HRAS(G12V) and SV40 LT are unable to form tumors.
From: Experimental evidence for cancer resistance in a bat species
a Representative images of bioluminescence signals in immunodeficient mice with xenografts derived from MSFHRAS\SV40LT and MPI-SFHRAS\SV40LT are captured at 1, 2, and 3 weeks after subcutaneous implantation. b The luciferase activity of the xenografts derived from MSFHRAS\SV40LT is significantly higher than that of the xenografts derived from MPI-SFHRAS\SV40LT at 2 and 3 weeks after subcutaneous implantation. c Representative images of the xenografts derived from MSFHRAS\SV40LT and MPI-SFHRAS\SV40LT after 3 weeks of subcutaneous implantation are shown. Scale bar: 1 cm. d The xenografts derived from MSFHRAS\SV40LT are significantly heavier than those derived from MPI-SFHRAS\SV40LT 3 weeks post subcutaneous implantation. All data are presented as mean ± SD. The P values are from two-tailed Student’s t tests. The number of dots (n = 5) represents the number of biologically independent animals. Source data are provided as a Source Data file.
