Fig. 5: Exploring the causal effects of continuous exposures on circulating retinol.
From: Genetic influences on circulating retinol and its relationship to human health
a Exposure traits that demonstrated a significant causal estimate (IVW-MRE) on circulating retinol after multiple-testing correction (FDR < 0.01). Traits are coloured relative to their broad phenotypic category. b Multivariable MR (MVMR) models investigating the effect of creatinine and major lipid species on circulating retinol. Each panel represents the results from a different MVMR model (each with different underlying assumptions (Online Methods). The exposure – retinol relationship plotted is conditional on the three other traits in the model.
