Fig. 3: C-N Bond Formation.
From: Challenges and recent advancements in the synthesis of α,α-disubstituted α-amino acids
a Copper-catalyzed radical addition at nitrosoarenes46. b Chiral catalysts used in the electrophilic and nucleophilic amination52. c Calculated transition states in Chinchilla’s solvent-free procedure58. d Synthesis of α,α-disubstituted α-amino esters via 1,4-acyl transfer64. e Nucleophilic approach for the construction of α,α-disubstituted α-amino esters67.
