Fig. 10: SEL1L protein levels are reduced in the lungs of patients with Pulmonary Fibrosis.
From: Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover
a, b Western blots of whole human lung lysates from Pulmonary Fibrosis lungs vs. control (donor lungs deemed not suitable for transplant), with corresponding densitometry. N = 13 in Control and 11 in Pulmonary Fibrosis group. Arrowheads correspond to two lung lysates that were used in both Western blots for normalization across blots, otherwise all other lanes are independent samples; p = 0.0352. c Representative low-power wide-field immunofluorescence images of human lungs (Pulmonary Fibrosis vs. control). Each row comes from an individual donor or Pulmonary Fibrosis lung, with two different fields per lung (i.e. N = 3 individual lungs per group). Data are shown as the mean ± SEM. Statistics: b unpaired Mann–Whitney U test (two-sided). *p < 0.05. Source data are provided as a Source Data file.
