Fig. 4: Patient case study of radiological response. | Nature Communications

Fig. 4: Patient case study of radiological response.

From: Repeated blood–brain barrier opening with a nine-emitter implantable ultrasound device in combination with carboplatin in recurrent glioblastoma: a phase I/II clinical trial

Fig. 4

Overall, tumor growth was better controlled within the field of sonication compared to outside the field of sonication in patients treated in Cohort D that received carboplatin infusion prior to sonication to disrupt the BBB. An example of the T1w contrast-enhanced evolution of the tumor volume from six monthly pre-sonication images is shown. This patient had an increase in T1 enhancement up to Cycle 2 that then decreased over time with each monthly cycle of treatment. The region outlined in green corresponds to nine cylinders, each 20 mm × 80 mm in front of each of the emitters of the ultrasound implant, which corresponds to the sonicated volume with an additional diffusion margin of 5 mm. Source data are provided as a Source Data file.

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